Aldosterone receptor antagonists are
medicines that help the body get rid of extra water (diuretics). They
also have other properties that can prevent
heart failure from becoming worse, along with
improving symptoms of heart failure.
These medicines cause the
kidneys to get rid of extra water and they help hold on to (retain)
potassium by inhibiting the action of the hormone aldosterone. Because of this,
they are called potassium-sparing diuretics.
Aldosterone receptor antagonist
medicines may be used if you have heart failure and you are
already taking other medicines (such as angiotensin-converting enzyme [ACE]
inhibitors and beta-blockers).footnote 1
Aldosterone receptor antagonists are
the only diuretics that improve survival for people with heart failure. They
lower the risk of death and hospitalization and improve symptoms of heart
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
Call 911 or other emergency services right away if you have:
Call your doctor if you have:
Common side effects of this medicine include:
See Drug Reference for a full list of side effects. (Drug
Reference is not available in all systems.)
You may feel more tired or need to urinate more often when you start taking this medicine. These effects typically occur less after you have taken the medicine for a while. If the increase in urine interferes with your sleep or daily activities, ask your doctor to help you plan a schedule for taking the medicine.
Your doctor may monitor the potassium in your blood with regular blood tests. Your doctor will let you know when you need to have the tests.
This diuretic does not make you lose potassium from your body like some other diuretics do. So you do not need to get extra potassium in your diet. Talk with your doctor or a dietitian before eating salt substitutes, because some salt substitutes contain potassium.
For information on other types of diuretics for heart failure, see Diuretics for Heart Failure.
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
For tips on taking medicine for heart failure, see:
If you are pregnant, breast-feeding, or trying to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breast-feeding, or planning to get pregnant.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
CitationsYancy CW, et al. (2013). 2013 ACCF/AHA Guideline for the management of heart failure: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology, 62(16): e147-e239.Drugs for treatment of chronic heart failure (2009). Treatment Guidelines From The Medical Letter, 7(83): 53-56.
ByHealthwise StaffPrimary Medical ReviewerRakesh K. Pai, MD, FACC - Cardiology, ElectrophysiologySpecialist Medical ReviewerMargaret Hetherington, PHM, BsC - Pharmacy
Current as ofOctober 19, 2016
Current as of:
October 19, 2016
Rakesh K. Pai, MD, FACC - Cardiology, Electrophysiology & Margaret Hetherington, PHM, BsC - Pharmacy
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Last modified on: 8 September 2017